颜宁

教授 中国科学院院士 美国科学院外籍院士 美国艺术与科学院外籍院士

主要科研领域与方向

主要运用结构生物学和生物化学手段系统研究跨膜运输蛋白的结构与机理。

主要研究方向如下：

1. 与疾病相关重要膜转运蛋白的结构与功能的研究；

2. 电压门控离子通道的结构与工作机理；

3. 胆固醇代谢调控机理。

代表性论文

1.     Xia Yao, Shuai Gao^#, Jixin Wang, Zhangqiang Li, Jian Huang, Yan Wang, Zhifei Wang, Jiaofeng Chen, Xiao Fan, Weipeng Wang, Xueqin Jin, Xiaojing Pan, Yong Yu, Armando Lagrutta, Nieng Yan^# (2022) Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Ca_v channels. Cell, 185(25):4801-4810.

2.     Shuai Gao, Xia Yao, Nieng Yan^# (2021) Structure of human Ca_v2.2 channel blocked by the painkiller ziconotide. Nature, 596(7870):143-147.

3.     Hongwu Qian^#, Xin Zhao, Renhong Yan, Xia Yao, Shuai Gao, Xue Sun, Ximing Du, Hongyuan Yang, Catherine C L Wong, Nieng Yan^# (2020) Structural basis for catalysis and substrate specificity of human ACAT1. Nature, 581(7808):333-338.

4.     Huaizong Shen, Dongliang Liu, Kun Wu, Jianlin Lei, Nieng Yan^# (2019) Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins. Science, 363(6433):1303-1308.

5.     Xiaojing Pan, Zhangqiang Li, Qiang Zhou, Huaizong Shen, Kun Wu, Xiaoshuang Huang, Jiaofeng Chen, Juanrong Zhang, Xuechen Zhu, Jianlin Lei, Wei Xiong, Haipeng Gong, Bailong Xiao, Nieng Yan^# (2018) Structure of the human voltage-gated sodium channel Na_v1.4 in complex with β1. Science, 362(6412): eaau2486.

6.     Huaizong Shen, Qiang Zhou, Xiaojing Pan, Zhangqiang Li, Jianping Wu, Nieng Yan^# (2017) Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution. Science, 355(6328): eaal4326.

7.     Wei Peng, Huaizong Shen, Jianping Wu, Wenting Guo, Xiaojing Pan, Ruiwu Wang, S. R. Wayne Chen^#, Nieng Yan^# (2016) Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2. Science, 354(6310): aah5324.

8.     Jianping Wu, Zhen Yan, Zhangqiang Li, Xingyang Qian, Shan Lu, Mengqiu Dong, Qiang Zhou & Nieng Yan^# (2016) Structure of the voltage-gated calcium channel Ca_v1.1 at 3.6 Å resolution. Nature, 537(7619): 191–196.

9.     Jianping Wu, Zhen Yan, Zhangqiang Li, Chuangye Yan, Shan Lu, Mengqiu Dong, and Nieng Yan^# (2015) Structure of the voltage-gated calcium channel Ca_v1.1 complex. Science, 350(6267): aad2395.

10. Dong Deng, Pengcheng Sun, Chuangye Yan, Meng Ke, Xin Jiang, Lei Xiong, Wenlin Ren, Kunio Hirata, Masaki Yamamoto, Shilong Fan & Nieng Yan^# (2015) Molecular basis of ligand recognition and transport by glucose transporters. Nature, 526(7573): 391-396.