祁海 博士

教授
国家杰出青年基金获得者 谈家桢生命科学创新奖获得者，
树兰奖获得者，美国免疫学会国际学者，
吴扬奖获得者

主要科研领域与方向

专注体液免疫应答调节机制，研究如下问题：

1. 生发中心反应关键性细胞互作的分子机理；2. 细胞互作的定性及定量特点如何参与细胞命运选择；3. 生发中心及滤泡组织结构的时空动态演化特点及分子调控机制；4. 以上3个层次的调控如何协同，既保持有效应答又同时避免自身反应；5. 记忆B细胞、长寿浆细胞发育与维持机制及疫苗应用；6. 中枢系统神经回路对免疫应答的调控机制。

代表性论文

1. Qingtai Liang, Yifeng Wang, Shuyuan Zhang, Jing Sun, Wenbo Sun, Jizhou Li, Yaping Liu, Mingxi Li, Lin Cheng, Yuhang Jiang, Ruoke Wang, Rui Zhang, Zihan Yang, Yifei Ren, Peng Chen, Peng Gao, Huayuan Yan, Zheng Zhang, Qi Zhang, Xuanling Shi, Jianbin Wang^#, Wanli Liu^#, Xinquan Wang^#,  Bo Ying^#,  Jincun Zhao^#,  Hai Qi^#, Linqi Zhang^#. RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants. iScience, 25:104043, 2022.

2. Bing Yang, Zhen Zhang, Xiangjun Chen, Xu-Yan Wang, Shishang Qin, Liaoqi Du, Changjiang Yang, Liyu Zhu, Wenbo Sun, Yongjie Zhu, Qinwen Zheng, Shidong Zhao, Quan Wang, Long Zhao, Yilin Lin, Jinghe Huang, Fan Wu, Lu Lu, Fei Wang, Wenjie Zheng, Xiao-Hua Zhou, Xiaozhen Zhao, Ziye Wang, Xiaolin Sun, Yingjiang Ye, Shan Wang, Zhanguo Li, Hai Qi, Zemin Zhang, Dong-Ming Kuang, Lei Zhang, Zhanlong Shen, Wanli Liu. An Asian-specific variant in human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment. Journal of Clinical Investigation, 132:e153454, 2022.

3. Xin Liu^#, Yongshan Zhao, Hai Qi^#.T-independent antigen induces humoral memory through germinal centers. Journal of Experimental Medicine, 219 e20210527, 2022. (doi:10.1084/jem.20210527)

4. Shiyue Hou*, Tiange Shao*, Tianyang Mao, Jingwen Shi, Jiahui Sun, Miao Mei Xu Tan, Hai Qi^#,  Virtual memory T cells orchestrate extralymphoid responses conducive to resident memory, Science Immunology, 6:eabg9433, 2021（DOI: 10.1126/sciimmunol.abg9433）

5. Dan Liu*, Jiacong Yan*, Jiahui Sun*, Bo Liu ,Weiwei Ma ,Ye Li, Xingxing Shao , Hai Qi^#, , BCL6 controls contact-dependent help delivery during follicular T-B cell interactions, Immunity, 54: 2245-2255.e4, 2021. ( DOI:10.1016/j.immuni.2021.08.003)

6. Linqi Zhang, Mingxi Li, Jingao Guo, Shuaiyao Lu, Runhong Zhou, Hongyang Shi, Xuanling Shi, Lin Cheng, Qingtai Liang, Hongqi Liu, Pui Wang, Nan Wang, Yifeng Wang, Lili Fu, Man Xing, Ruoke Wang, Bin Ju, Li Liu, Siu-Ying Lau, Wenxu Jia, Xin Tong, Lin Yuan, Yong Guo, Hai Qi, Qi Zhang, Zhen Huang, Honglin Chen, Zheng Zhang, Zhiwei Chen, Xiaozhong Peng, Dongming Zhou, Single-Dose Immunization With a Chimpanzee Adenovirus-Based Vaccine Induces Sustained and Protective Immunity Against SARS-CoV-2 Infection，Frontiers in Immunology，2021.(DOI:10.3389/fimmu.2021.697074)

7. Bo Liu, Yihan Lin, Jiacong Yan, Jiacheng Yao, Dan Liu, Weiwei Ma, Jianbin Wang, Wanli Liu, Chengshuo Wang, Luo Zhang, and Hai Qi#. Affinity-coupled CCL22 promotes germinal-center positive selection. Nature, 592:133-137, 2021. (DOI: 10.1038/s41586-021-03239-2)

8. Dan Liu*, Jiacong Yan*, Jiahui Sun*, Bo Liu ,Weiwei Ma ,Ye Li, Xingxing Shao , Hai Qi^#,  BCL6 controls contact-dependent help delivery during follicular T-B cell interactions, Immunity, 2021.( DOI:10.1016/j.immuni.2021.08.003)

9. Ruozhu Zhao, Xin Chen, Weiwei Ma, Jinyu Zhang, Jie Guo, Xiu Zhong, Jiacheng Yao, Jiahui Sun, Julian Rubinfien, Xuyu Zhou, Jianbin Wang,Hai Qi^#.(2020) A GPR174-CCL21 module imparts sexual dimorphism to humoral immunity. Nature, 577:416-420.

10. Xu Zhang^*, Bo Lei^*, Yuan Yuan^*, Li Zhang^*, Lu Hu, Sen Jin, Bilin Kang, Xuebin Liao, Wenzhi Sun, Fuqiang Xu, Yi Zhong^#, Ji Hu^#, Hai Qi^#.(2020) Brain control of humoral immune responses amenable to behavioral modulation. Nature, 581:204-208.

11. Jingwen Shi, Shiyue Hou, Qian Fang, Xin Liu, Xiaolong Liu, Hai Qi^#.(2018) Regulation of follicular T-helper cell positioning and function by PD-1. Immunity, 49:264-274.

12. Peiwen Lu^*, Changming Shih^*,Hai Qi^#.(2017)Ephrin B1–mediated repulsion and signaling control germinal center T cell territoriality and function. Science, 356:eaai9264.

13. Ran He^*, Shiyue Hou^*, Cheng Liu^*, Anli Zhang, Qiang Bai, Miao Han, Yu Yang, Gang Wei, Ting Shen, Xinxin Yang, Lifan Xu, Xiangyu Chen, Yaxing Hao, Chuhong Zhu, Juanjuan Ou, Houjie Liang, Ting Ni, Xiaoyan Zhang, Xinyuan Zhou, Jianqing Xu, Hai Qi^#, Yuzhang Wu^#, Lilin Ye^#.(2016)Follicular CXCR5-expressing CD8 T cells curtail chronic viral infection. Nature, 537:412-428.

14. Dan Liu^*, Heping Xu^*, Changming Shih, Zurong Wan, Xiaopeng Ma, Weiwei Ma, Dan Luo,Hai Qi^#.(2015)T-B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction. Nature, 517:214-218.

15. Xin Chen^*, Shan Tang^*, Ji-Shen Zheng^*, Ruozhu Zhao, Zhi-Peng Wang, Wen Shao, Hao-Nan Chang, Jing-Yuan Cheng, Hui Zhao, Lei Liu^#,Hai Qi^#.(2015)Chemical synthesis of a two-photon-activatable chemokine and photon-guided lymphocyte migration in vivo. Nature Communications,6:7220.

16. Heping Xu, Xuanying Li, Dan Liu, Jianfu Li, Xu Zhang, Xin Chen, Shiyue Hou, Lixia Peng, Chenguang Xu, Wanli Liu, Lianfeng Zhang, Hai Qi^#.(2013) Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility. Nature, 496:523-527.