联系方式

电话:+86-10-62782124

邮箱:jwwang@tsinghua.edu.cn

王佳伟 博士

副教授

个人履历

1996-2001中国科学技术大学材料科学与工程系 学士

2001-2005中国科学院物理研究所 博士

2005-2008美国阿岗国家实验室/国立癌症研究所蛋白质晶体学实验室/SAIC-Frederick Inc. 博士后

2008-2011清华大学生命科学学院 高级工程师

2011-2017清华大学生命科学学院 助理教授

2017-至今清华大学生命科学学院 副教授

主要科研领域与方向

膜蛋白晶体学:利用X射线晶体学解析与重大疾病相关的膜蛋白的晶体结构,同时探索利用细聚焦光束线测定微小膜蛋白晶体结构的技术,及微小晶体衍射相位的获取和结构分析等关键科学问题。

代表性论文

1.     Xiaofei Ge, Jiawei Wang# (2024). Structural mechanism of bacteriophage lambda tail’s interaction with the bacterial receptor. Nature Communications, 15(1):4185.

2.     Zhiwei Gu, Kexun Wu, Jiawei Wang# (2024). Structural morphing in the viral portal vertex of bacteriophage lambda. Journal of Virology, 98(5):e0006824.

3.     Chang Wang, Jinsong Duan, Zhiwei Gu, Xiaofei Ge, Jianwei Zeng#, Jiawei Wang# (2024). Architecture of the bacteriophage lambda tail. Structure, 32(1):35-46.e3.

4.     Ruilian Li, Jinsong Duan, Yicheng Zhou, Jiawei Wang# (2023). Structural basis of the mechanisms of action and immunity of Lactococcin A, a class IId bacteriocin. Appl Environ Microbiol. 89(3):e0006623.

5.     Chang Wang, Jianwei Zeng#, Jiawei Wang# (2022) Structure basis of bacteriophage lambda capsid maturation. Structure. 30(4):637-645.e3.

6.     Liyan Zhu, Jianwei Zeng, Jiawei Wang# (2022). Structural basis of the immunity mechanisms of pediocin-like bacteriocins. Appl Environ Microbiol. 88(13):e0048122.

7.     Liyan Zhu, Jianwei Zeng, Chang Wang, Jiawei Wang# (2022) Structural basis of pore formation in the mannose phosphotransferase system by pediocin PA-1. Appl Environ Microbiol. 88(3):e0199221.

8.     Kai Huang, Jianwei Zeng, Xueli Liu, Tianyu Jiang#, Jiawei Wang# (2021) Structure of the mannose phosphotransferase system (man-PTS) complexed with microcin E492, a pore-forming bacteriocin. Cell Discovery, 7(1):20.

9.     Linghui Li, Shuliu Dai, George F Gao#, Jiawei Wang# (2020) Lattice-translocation defects in specific crystals of the catalytic head domain of influenza neuraminidase. Acta Crystallogr D Struct Biol. 76:1057-1064.

10. Xueli Liu, Jianwei Zeng, Kai Huang, Jiawei Wang# (2019) Structure of the mannose transporter of the bacterial phosphotransferase system. Cell Research, 29(8):680-682.