电话：+86-10-62792606
传真：+86-10-62792736
邮箱：maojunyang@tsinghua.edu.cn
教授
国家杰出青年基金获得者
1995-1999吉林大学生命科学学院 学士
1999-2003北京协和医院基础医学研究所 博士
2004-2008德克萨斯大学西南医学中心 博士后
2008-2013清华大学生命科学学院 特别研究员
2013-至今清华大学生命科学学院 教授
主要以结构生物学结合细胞与分子生物学和生物化学为研究手段，从事细胞感应外界信号以及细胞能量代谢相关蛋白质的结构与功能研究，并以这些生物大分子的高分辨结构为基础开展药物设计及临床应用研究。
1. Xudong Chen, Min Xie, Sensen Zhang, Marta Monguió-Tortajada, Jian Yin, Chang Liu, Youqi Zhang, Maeva Delacrétaz, Mingyue Song, Yixue Wang, Lin Dong, Qiang Ding, Boda Zhou, Xiaolin Tian, Haiteng Deng, Lina Xu, Xiaohui Liu, Zi Yang, Qing Chang, Jie Na, Wenwen Zeng, Giulio Superti-Furga, Manuele Rebsamen, Maojun Yang# (2023) Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling. Nature Communications. Oct 20;14(1):6627.
2. Jinke Gu, Tianya Liu, Runyu Guo, Laixing Zhang, Maojun Yang#. (2022) The coupling mechanism of mammalian mitochondrial complex I. Nat Struct Mol Biol. Feb;29(2):172-182.
3. Jinke Gu, Laixing Zhang, Shuai Zong, Runyu Guo, Tianya Liu, Jingbo Yi, Peiyi Wang, Wei Zhuo, Maojun Yang*.(2019) Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1. Science, 364(6445):1068-1075.
4. Shuai Zong, Meng Wu, Jinke Gu, Tianya Liu, Runyu Guo, Maojun Yang*. (2018) Structure of the intact 14-subunit human cytochrome c oxidase. Cell Res. 28(10):1026-1034.
5. Runyu Guo, Shuai Zong, Meng Wu, Jinke Gu, Maojun Yang*. (2017) Architecture of human mitochondrial respiratory megacomplex I2III2IV2. Cell, 170(6):1247-1257.
6. Meng Wu, Jinke Gu, Runyu Guo, Yushen Huang, Maojun Yang*.(2016) Structure of mammalian respiratory supercomplex I1III2IV1. Cell, 167(6):1598-1609.
7. Jinke Gu, Meng Wu, Runyu Guo, Kaige Yan, Jianlin Lei, Ning Gao*, Maojun Yang*. (2016) The architecture of the mammalian respirasome. Nature, 537(7622):639-643. (Article)
8. Jingpeng Ge, Wanqiu Li, Qiancheng Zhao, Ningning Li, Maofei Chen, Peng Zhi, Ruochong Li, Ning Gao*, Bailong Xiao*, Maojun Yang*.(2015) Architecture of the Mammalian Mechanosensitive Piezo1 Channel. Nature, 527(7576):64-69. (Article)
9. Jie Yu, Jingpeng Ge, Johanna Heuveling, Erwin Schneider, Maojun Yang*. (2015) Structural basis for substrate
specificity of an amino acid ABC transporter. Proc Natl Acad Sci U S A., Apr 21;112(16):5243-8.
10. Yue Feng, Wenfei Li, Jian Li, Jiawei Wang, Jingpeng Ge, Duo Xu, Yanjing Liu, Kaiqi Wu, Qingyin Zeng, Jiawei Wu, Changlin Tian, Bing Zhou, Maojun Yang*. (2012) Structural insight into the type-II mitochondrial NADH dehydrogenases. Nature. Nov 15;491(7424):478-82.
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