邮箱：xbailong@mail.tsinghua.edu.cn
教授
国家杰出青年科学基金获得者
国家优秀青年科学基金获得者
1997-2001中山大学生物化学系 学士
2001-2006加拿大卡尔加里大学 博士
2007-2012斯克利普斯研究所 博士后
2013-2015清华大学医学院药学系 Tenure-track助理教授
2015-2018清华大学药学院 准聘副教授
2018-2021清华大学药学院 长聘副教授
2021-至今 清华大学药学院 长聘教授
研究方向包括：
1. 从原子级别空间尺度、毫秒级别时间尺度、皮安级别电流尺度以及皮牛级别力学尺度，深入探究Piezo通道的动态机械门控机制以及调控机制；
2. 揭示Piezo 通道如何利用其生物物理特性决定其重要的生理病理功能；
3. 发现与开发Piezo通道药物与技术；
4. 鉴定发现新型机械门控离子通道及其调控蛋白。
1. Bailong Xiao*.(2024) Mechanisms of mechanotransduction and physiological roles of PIEZO channels. Nature Reviews Molecular and Cell Biology 2024.
2. Tingxin Zhang#, Cheng Bi#, Yiran Li#, Lingyun Zhao, Yaxiong Cui, Kunfu Ouyang*, and Bailong Xiao*. (2024) Phosphorylation of Piezo1 at a single residue Serine-1612 regulates its mechanosensitivity and in vivo mechanotransduction function. Neuron 2024.
3. Celeste M. Nelson, Bailong Xiao, Sara A. Wickström, Yves F. Dufrêne, Daniel J. Cosgrove, Carl-Philipp Heisenberg, Sirio Dupont, Amy E. Shyer , Alan R. Rodrigues, Xavier Trepat, Alba Diz-Muñoz (2024) Mechanobiology: Shaping the future of cellular form and function. Cell, VOICES| VOLUME 187, ISSUE 11, P2652-2656, MAY 23, 2024.
4. Shaopeng Chi* Yaxiong Cui*, Haiping Wang*, Jinghui Jiang, Tingxin Zhang, Suhua Sun, Zhuan Zhou, Yi Zhong, Bailong Xiao# (2022) Astrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions. Neuron. 2022 Sep 21;110(18):2984-2999.e8.
5. Xuzhong Yang#, Chao Lin#, Xudong Chen#, Shouqin Li#, Xueming Li*, Bailong Xiao*.(2022) Structure deformation and curvature sensing of PIEZO1 in lipid membranes. Nature (Article) 2022 Apr;604(7905):377-383.
6. Jie Geng, Wenhao Liu, Heng Zhou, Tingxin Zhang, Li Wang, Mingmin Zhang, Yiran Li, Bo Shen, Xueming Li#, Bailong Xiao# (2020) A plug-and-latch mechanism for gating the mechanosensitive Piezo channel. Neuron. 2020 May 6;106(3):438-451.
7. Li Wang, Heng Zhou, Mingmin Zhang, Wenhao Liu, Tuan Deng, Qiancheng Zhao, Yiran Li, Jianlin Lei, Xueming Li*, Bailong Xiao*. (2019) Structure and mechanogating of the mammalian tactile channel PIEZO2. Nature (Article) 2019 Sep;573(7773):225-229.
8. Qiancheng Zhao, Heng Zhou, Shaopeng Chi, Yanfeng Wang, Jianhua Wang, Jie Geng, Kun Wu, Wenhao Liu, Tingxin Zhang, Meng-Qiu Dong, Jiawei Wang, Xueming Li*, Bailong Xiao* (2018) Structure and Mechanogating Mechanism of the Piezo1 Channel. Nature (Article) 2018 Feb 22;554(7693):487-492.
9. Jingpeng Ge, Wanqiu Li*, Qiancheng Zhao*, Ningning Li*, Maofei Chen, Peng Zhi, Ruochong Li, Ning Gao#, Bailong Xiao#, Maojun Yang# (2015). Architecture of the mammalian mechanosensitive Piezo1 channel. Nature (Article) 2015 Nov 5;527(7576):64-9.
10. Bertrand Coste* (co-first), Bailong Xiao* (co-first), Jose S. Santos, Ruhma Syeda, Jorg Grandl, Kathryn S. Spencer, Sung Eun Kim, Manuela Schmidt, Jayanti Mathur, Adrienne E. Dubin, Mauricio Montal, Ardem Patapoutian (2012). Piezo Proteins Are Pore-forming Subunits of Mechanically Activated Channels. Nature （Article） 2012 Feb 19;483(7388):176-81
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