联系方式

邮箱:xbailong@mail.tsinghua.edu.cn

肖百龙 博士

教授
国家杰出青年科学基金获得者
国家优秀青年科学基金获得者

个人履历

1997-2001中山大学生物化学系 学士

2001-2006加拿大卡尔加里大学 博士

2007-2012斯克利普斯研究所 博士后

2013-2015清华大学医学院药学系 Tenure-track助理教授

2015-2018清华大学药学院 准聘副教授

2018-2021清华大学药学院 长聘副教授

2021-至今 清华大学药学院 长聘教授

主要科研领域与方向

研究方向包括:

1. 从原子级别空间尺度、毫秒级别时间尺度、皮安级别电流尺度以及皮牛级别力学尺度,深入探究Piezo通道的动态机械门控机制以及调控机制;

2. 揭示Piezo 通道如何利用其生物物理特性决定其重要的生理病理功能;

3. 发现与开发Piezo通道药物与技术;

4. 鉴定发现新型机械门控离子通道及其调控蛋白。

代表性论文

1. Xuzhong Yang#, Chao Lin#, Xudong Chen#, Shouqin Li#, Xueming Li*, Bailong Xiao*.(2022) Structure deformation and curvature sensing of PIEZO1 in lipid membranes. Nature (Article) 2022 Apr;604(7905):377-383.
2. Li Wang, Heng Zhou, Mingmin Zhang, Wenhao Liu, Tuan Deng, Qiancheng Zhao, Yiran Li, Jianlin Lei, Xueming Li*, Bailong Xiao*. (2019) Structure and mechanogating of the mammalian tactile channel PIEZO2. Nature (Article) 2019 Sep;573(7773):225-229.
3. Qiancheng Zhao, Heng Zhou, Shaopeng Chi, Yanfeng Wang, Jianhua Wang, Jie Geng, Kun Wu, Wenhao Liu, Tingxin Zhang, Meng-Qiu Dong, Jiawei Wang, Xueming Li*, Bailong Xiao* (2018) Structure and Mechanogating Mechanism of the Piezo1 Channel. Nature (Article) 2018 Feb 22;554(7693):487-492.
4. Jingpeng Ge, Wanqiu Li*, Qiancheng Zhao*, Ningning Li*, Maofei Chen, Peng Zhi, Ruochong Li, Ning Gao#, Bailong Xiao#, Maojun Yang# (2015). Architecture of the mammalian mechanosensitive Piezo1 channel. Nature(Article)  2015 Nov 5;527(7576):64-9.
5. Bertrand Coste* (co-first), Bailong Xiao* (co-first), Jose S. Santos, Ruhma Syeda, Jorg Grandl, Kathryn S. Spencer, Sung Eun Kim, Manuela Schmidt, Jayanti Mathur, Adrienne E. Dubin, Mauricio Montal, Ardem Patapoutian (2012). Piezo Proteins Are Pore-forming Subunits of Mechanically Activated Channels. Nature (Article) 2012 Feb 19;483(7388):176-81
6. Jie Geng, Wenhao Liu, Heng Zhou, Tingxin Zhang, Li Wang, Mingmin Zhang, Yiran Li, Bo Shen, Xueming Li#, Bailong Xiao# (2020) A plug-and-latch mechanism for gating the mechanosensitive Piezo channel. Neuron. 2020 May 6;106(3):438-451.
7. Qiancheng Zhao, Kun Wu, Jie Geng, Shaopeng Chi, Yanfeng Wang, Peng Zhi, Mingmin Zhang, Bailong Xiao* (2016). Ion Permeation and Mechanotransduction Mechanisms of Mechanosensitive Piezo Channels. Neuron. 2016 Mar 16;89(6):1248-63.
8. Fan Jiang, Kunlun Yin, Kun Wu, Mingmin Zhang, Shiqiang Wang, Heping Cheng, Zhou Zhou, Bailong Xiao# (2021) The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction. Nature Commun. 2021 Feb 8;12(1):869. 
9. Yang Jiang*, Xuzhong Yang*, Jinghui Jiang*, Bailong Xiao# (2021) Structural Designs and Mechanogating of the Mechanosensitive Piezo channels. Trends Biochem Sci. 2021 Feb 17:S0968-0004(21)00022-0. 
10. Bailong Xiao*. (2020) Levering mechanically activated Piezo channels for potential pharmacological intervention. Annual Review of Pharmacology and Toxicology , 2020 Jan 6;60:195-218.